Metformin

There is a lot of evidence showing that metformin is beneficial for PCa patients.

https://pubmed.ncbi.nlm.nih.gov/28444639/

https://pubmed.ncbi.nlm.nih.gov/30651580/

https://pubmed.ncbi.nlm.nih.gov/30012567/

But a recent study shows that metformin blunts some of the positive changes from exercise.

onlinelibrary.wiley.com/doi…

Metformin in combination with rapamycin might be positive. I take a low dose of rapa once a week.

cancerpreventionresearch.aa…

I have been taking 1500mg of metformin a day since a few years before my PCa diagnosis (based on my PSA I almost certainly had PCa prior to my metformin use). Until I see more studies on exercise and metformin I think I might cycle it 3 months on and 1 month off (I swag the efficacy at 75% Lol!). An SOC urologist at Mayo has studied it and begged me to go off of it completely. He said that we just don’t know all that it might be doing to glucose pathways, mitochondria, etc.